Biology, University of Dundee
Tenure since 2016
Role of Adipose β-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) in Insulin Resistance
Aimée’s project will focus on studying the specific role of BACE1 in fat tissues in insulin resistance (IR), as previous studies have suggested that BACE1 modulates insulin sensitivity and blood glucose levels possibly by modulating the inflammatory and immune responses in fat cells. BACE1 (β-site amyloid precursor protein cleaving enzyme 1), the enzyme primarily responsible for producing Aβs is upregulated in the brain tissue of AD (Alzheimer’s disease) patients, thus driving high Aβ levels. Besides brain, BACE1 is also expressed in organs sensitive to the hormone insulin in controlling blood glucose such as muscle, liver and fat. It is shown that BACE1 is more active with obesity and insulin resistance (IR). IR, where the cells fail to respond to insulin to lower glucose in the blood is a hallmark of T2DM. These studies will also provide evidence for future therapeutic use of BACE1 inhibitors in diseases.
After completing her primary and secondary education in France, Aimée pursued her undergraduate degree in Anatomy & Physiology at the University of Dundee. At the end of her third year, Aimée was awarded the Lippincott Human Anatomy prize and the Ede & Ravenscroft prize for her academic excellence. At the end of her fourth year, Aimée obtained a first class honours degree in anatomy and physiology. During the summer of 2015, Aimée was part of the Dundee iGEM team, which went on to win a gold medal at the international competition in Boston. Aimée then went on to study for an integrated Masters in Immunology, graduating with a first class Msci in Physiology in 2016.